A comprehensive manual is supplied with the software and there is a detailed Help file. The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect. All data and results are easily accessible by mouse-click on the contents tree. CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, and graphics packages.
#Calcusyn 2.0 plus#
CalcuSyn automatically graphs the data and produces reports giving summary statistics on all drugs plus detailed analysis of drug interactions including the Combination Index and EDx (for any value of x). Estimates of accuracy of EDx and CI can be calculated with Monte Carlo simulations or by a highly accurate algebraic estimation algorithm. Data can be processed both for individual drugs, and for constant-ratio or non-constant-ratio combinations of drugs.
When the grid is used, data can be processed through wizards which make the software easily accessible to new users. Data can be entered via the keyboard or file import either into the grid or directly into the analysis engine. 4, 450-454). CalcuSyn can easily be integrated with other software. CalcuSyn performs multiple drug dose-effect calculations using the Median Effect methods described by T-C Chou and P.
CalcuSyn Version 2.0 is the analyzer of combined drug effects, able automatically to quantify phenomena such as synergism and inhibition. The use of combined drug treatments is becoming common in the treatment of cancer and AIDS.
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